Integrative Analysis of DNA Methylation Identified 12 Signature Genes Specific to Metastatic ccRCC.

ABSTRACT: Background: Abnormal epigenetic alterations can contribute to the development of human malignancies. Identification of these alterations for early screening and prognosis of clear cell renal cell carcinoma (ccRCC) has been a highly sought-after goal. Bioinformatic analysis of DNA methylation data provides broad prospects for discovery of epigenetic biomarkers. However, there is short of exploration of methylation-driven genes of ccRCC. Methods: Gene expression data and DNA methylation data in metastatic ccRCC were sourced from the Gene Expression Omnibus (GEO) database. Differentially methylated genes (DMGs) at 5'-C-phosphate-G- 3' (CpG) sites and differentially expressed genes (DEGs) were screened and the overlapping genes in DMGs and DEGs were then subject to gene set enric

SUBMITTER: Qian S 

PROVIDER: S-EPMC7578385 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature