Performance of ¹⁸F-FDG PET/CT Radiomics for Predicting EGFR Mutation Status in Patients With Non-Small Cell Lung Cancer.

ABSTRACT:

Objective

To assess the performance of pretreatment ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) radiomics features for predicting EGFR mutation status in patients with non-small cell lung cancer (NSCLC).

Patients and methods

We enrolled total 173 patients with histologically proven NSCLC who underwent preoperative ¹⁸F-FDG PET/CT. Tumor tissues of all patients were tested for EGFR mutation status. A PET/CT radiomics prediction model was established through multi-step feature selection. The predictive performances of radiomics model, clinical features and conventional PET-derived semi-quantitative parameters were compared using receiver operating curves (ROCs) analysis.

Results

Four CT and two

SUBMITTER: Zhang M 

PROVIDER: S-EPMC7578399 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature