Keratin 17 is an imaging biomarker in lung cancers.

ABSTRACT:

Background

Computed tomographic (CT) features have demonstrated their value in classifying and assessing pulmonary nodules. Additionally, recent studies have shown the presence of keratin 17 (K17) in lung cancer is associated with increased mortality compared to patients with low/no K17 expression. The purpose of this study is to determine if there are CT imaging features that correlate with overexpression of K17 in patients with lung cancer.

Methods

This retrospective cohort study was approved by an Institutional Review Board. Lung cancer in 67 consecutive patients, who consented to have their lung cancer tissue stored in a tissue bank, were revaluated by immunohistochemical staining for the presence or absence of K17. Pre-operative imaging studies were collected on all pat

SUBMITTER: Bhattacharji P 

PROVIDER: S-EPMC7578507 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature