Tumor density is associated with response to endobronchial ultrasound-guided transbronchial needle injection of cisplatin.

ABSTRACT:

Background

Endobronchial ultrasound-guided transbronchial needle injection of cisplatin (EBUS-TBNI cisplatin) is a therapeutic option for patients with recurrent lung cancer. However, the tumor characteristics that influence the distribution of the agent following intratumoral delivery remain largely unknown.

Methods

We performed a retrospective evaluation of EBUS-TBNI cisplatin cases performed at two centers. Semi-automated tumor segmentation from CT scans was performed while blinded to the outcome of response. Twenty-four algorithmic radiomics features from two categories, Morphology (i.e., shape, volume) and Intensity (i.e., density), were extracted, and feature selection performed via least absolute shrinkage and selection operator (LASSO) regression. Models were constru

SUBMITTER: Kinsey CM 

PROVIDER: S-EPMC7578514 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature