Effects of vonoprazan on gastric PH and clinical course after gastric ESD: A retrospective and prospective study.

ABSTRACT:

Background

Vonoprazan has been more widely used for artificial ulcers after endoscopic submucosal dissection (ESD) for early gastric cancer; however, no reports have examined intragastric pH during ESD. The present study aimed to measure gastric pH at the time of ESD and the clinical course afterwards for patients treated with vonoprazan the night before undergoing ESD.

Materials and methods

We examined medication status regarding gastric acid secretion and antithrombotic drugs, post-ESD bleeding as a perioperative complication, and the timing of upper gastrointestinal endoscopy after ESD and ulcer healing in 156 patients who underwent gastric ESD at our hospital from January 2014 to December 2019. The gastric pH was measured at the time of ESD after administration of 20 mg

SUBMITTER: Suto D 

PROVIDER: S-EPMC7578543 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature