Chasing coevolutionary signals in intrinsically disordered proteins complexes.

ABSTRACT: Intrinsically disordered proteins/regions (IDPs/IDRs) are crucial components of the cell, they are highly abundant and participate ubiquitously in a wide range of biological functions, such as regulatory processes and cell signaling. Many of their important functions rely on protein interactions, by which they trigger or modulate different pathways. Sequence covariation, a powerful tool for protein contact prediction, has been applied successfully to predict protein structure and to identify protein-protein interactions mostly of globular proteins. IDPs/IDRs also mediate a plethora of protein-protein interactions, highlighting the importance of addressing sequence covariation-based inter-protein contact prediction of this class of proteins. Despite their importance, a systematic approach t

SUBMITTER: Iserte JA 

PROVIDER: S-EPMC7578644 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature