Development and validation of MMR prediction model based on simplified clinicopathological features and serum tumour markers.

ABSTRACT:

Background

Although simplified clinicopathological features and serum tumour markers (STMs) were reported to be associated with the status of mismatch repair (MMR) in colorectal cancer (CRC) patients, their predictive value alone or in combination for MMR status remains unknown.

Methods

A retrospective analysis of 3274 participants with MMR testing and STMs measurements from two institutions was conducted. The prediction model was developed in the primary cohort that consisted of 1964 participants. Best subset regression was applied to select the most useful predictors from the primary dataset. The performance of the nomogram was evaluated with respect to its calibration, discrimination, and clinical usefulness. External validation was performed in an independent validation

SUBMITTER: Cao Y 

PROVIDER: S-EPMC7578682 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature