Prevalence of NPHS2 gene R229Q polymorphism in Bangladeshi children with nephrotic syndrome.

ABSTRACT:

Background

Limited and contradictory pharmacogenetic studies of NPHS2 gene R229Q polymorphism in nephrotic syndrome (NS) children of different ethnicities steered us to investigate the genotype frequency and associated risk of this polymorphism in Bangladeshi NS children.

Methods

A prospective case-control study was conducted which comprised a total of 142 children having nephrotic syndrome (NS), divided into 2 groups: case group consisted of 40 children with steroid-resistant nephrotic syndrome (SRNS), and control group involved 102 children with steroid-sensitive nephrotic syndrome (SSNS). Both were genotyped by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method for R229Q polymorphism.

Results

The results indicate the p

SUBMITTER: Jyoti SS 

PROVIDER: S-EPMC7578689 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature