Possible Susceptibility Genes for Intervention against Chemotherapy-Induced Cardiotoxicity.

ABSTRACT: Recent therapeutic advances have significantly improved the short- and long-term survival rates in patients with heart disease and cancer. Survival in cancer patients may, however, be accompanied by disadvantages, namely, increased rates of cardiovascular events. Chemotherapy-related cardiac dysfunction is an important side effect of anticancer therapy. While advances in cancer treatment have increased patient survival, treatments are associated with cardiovascular complications, including heart failure (HF), arrhythmias, cardiac ischemia, valve disease, pericarditis, and fibrosis of the pericardium and myocardium. The molecular mechanisms of cardiotoxicity caused by cancer treatment have not yet been elucidated, and they may be both varied and complex. By identifying the functional geneti

SUBMITTER: Yang X 

PROVIDER: S-EPMC7578723 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature