Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis.

ABSTRACT: The peptidoglycan layer is responsible for maintaining bacterial cell shape and permitting cell division. Cell wall growth is facilitated by peptidoglycan synthases and hydrolases and is potentially modulated by components of the central carbon metabolism. In Bacillus subtilis, UgtP synthesises the glucolipid precursor for lipoteichoic acid and has been suggested to function as a metabolic sensor governing cell size. Here we show that ugtP mutant cells have increased levels of cell wall precursors and changes in their peptidoglycan that suggest elevated DL-endopeptidase activity. The additional deletion of lytE, encoding a DL-endopeptidase important for cell elongation, in the ugtP mutant background produced cells with severe shape defects. Interestingly, the ugtP lytE mutant recovered nor

SUBMITTER: Sassine J 

PROVIDER: S-EPMC7578834 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature