Evidence for the existence of CD34⁺ angiogenic stem cells in human first-trimester decidua and their therapeutic for ischaemic heart disease.

ABSTRACT: Stem cell transplantation is nearly available for clinical application in the treatment of ischaemic heart disease (IHD), where it may be joined traditional methods (intervention and surgery). The angiogenic ability of seed cells is essential for this applicability. The aim of this study was to reveal the presence of CD34⁺ angiogenic stem cells in human decidua at the first trimester and to use their strong angiogenic capacity in the treatment of IHD. In vitro, human decidual CD34⁺ (dCD34⁺ ) cells from the first trimester have strong proliferation and clonality abilities. After ruling out the possibility that they were vascular endothelial cells and mesenchymal stem cells (MSCs), dCD34⁺ cells were found to be able to form tube structures after di

SUBMITTER: Bai L 

PROVIDER: S-EPMC7578869 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature