Metal-Specific Biomaterial Accumulation in Human Peri-Implant Bone and Bone Marrow.

ABSTRACT: Metallic implants are frequently used in medicine to support and replace degenerated tissues. Implant loosening due to particle exposure remains a major cause for revision arthroplasty. The exact role of metal debris in sterile peri-implant inflammation is controversial, as it remains unclear whether and how metals chemically alter and potentially accumulate behind an insulating peri-implant membrane, in the adjacent bone and bone marrow (BM). An intensively focused and bright synchrotron X-ray beam allows for spatially resolving the multi-elemental composition of peri-implant tissues from patients undergoing revision surgery. In peri-implant BM, particulate cobalt (Co) is exclusively co-localized with chromium (Cr), non-particulate Cr accumulates in the BM matrix. Particles consisting of

SUBMITTER: Schoon J 

PROVIDER: S-EPMC7578891 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature