Customizable 3D-Printed (Co-)Cultivation Systems for In Vitro Study of Angiogenesis.

ABSTRACT: Due to the ever-increasing resolution of 3D printing technology, additive manufacturing is now even used to produce complex devices for laboratory applications. Personalized experimental devices or entire cultivation systems of almost unlimited complexity can potentially be manufactured within hours from start to finish-an enormous potential for experimental parallelization in a highly controllable environment. This study presents customized 3D-printed co-cultivation systems, which qualify for angiogenesis studies. In these systems, endothelial and mesenchymal stem cells (AD-MSC) were indirectly co-cultivated-that is, both cell types were physically separated through a rigid, 3D-printed barrier in the middle, while still sharing the same cell culture medium that allows for the exchange of

SUBMITTER: Siller IG 

PROVIDER: S-EPMC7579111 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature