A Comprehensive Assessment of the Associations Between Season of Conception and Birth Defects, Texas, 1999-2015.

ABSTRACT: Birth defects prevalence may vary seasonally, but previous studies have focused on a few commonly occurring phenotypes. We performed a phenome-wide association study (PheWAS) in order to evaluate the associations between season of conception and a broad range of birth defects. Date of conception was estimated for all livebirths and birth defect cases in Texas from 1999-2015 using data from vital records, provided by the Texas Department of State Health Services Center for Health Statistics. Birth defects diagnoses were obtained from the Texas Birth Defects Registry, a statewide, active surveillance system. We estimated prevalence ratios (PRs) for phenotypes with ≥50 cases according to conception in spring (March-May), summer (June-August) or fall (September-November) relative to winter (De

SUBMITTER: Benavides E 

PROVIDER: S-EPMC7579376 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature