Diabetic nephropathy associates with deregulation of enzymes involved in kidney sulphur metabolism.

ABSTRACT: Nephropathy is a major chronic complication of diabetes. A crucial role in renal pathophysiology is played by hydrogen sulphide (H₂ S) that is produced excessively by the kidney; however, the data regarding H₂ S bioavailability are inconsistent. We hypothesize that early type 1 diabetes (T1D) increases H₂ S production by a mechanism involving hyperglycaemia-induced alterations in sulphur metabolism. Plasma and kidney tissue collected from T1D double transgenic mice were subjected to mass spectrometry-based proteomic analysis, and the results were validated by immunological and gene expression assays.T1D mice exhibited a high concentration of H₂ S in the plasma and kidney tissue and histological, showed signs of subtle kidney fibrosis, characteris

SUBMITTER: Uyy E 

PROVIDER: S-EPMC7579703 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature