Mutations in the notch signalling pathway are associated with enhanced anti-tumour immunity in colorectal cancer.

ABSTRACT: The Notch signalling pathway is involved in the development of several cancers, including colorectal cancer (CRC). However, whether mutations in this pathway could alter the CRC immunophenotype remains unknown. Here, we investigated the relationship between Notch signalling pathway mutations and the tumour immune microenvironment by analysing gene expression data from the GSE108989 single T cell RNA sequencing data set and The Cancer Genome Atlas (TCGA) data set. We found that Notch signalling pathway mutations were associated with an increased number of tumour-specific CD8⁺ T cells and decreased number of inhibitory regulatory T (Treg) cells, representing an enhanced anti-tumour response in the GSE108989 data set. In TCGA data set, we also found that Notch signalling pathway mu

SUBMITTER: Wang F 

PROVIDER: S-EPMC7579712 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature