MiR-34a-5p Attenuates EMT through targeting SMAD4 in silica-induced pulmonary fibrosis.

ABSTRACT: Silicosis is an incurable occupational disease, and its pathological feature is diffuse pulmonary fibrosis. Pulmonary epithelial-mesenchymal transition (EMT) is one of the important events in the pathogenesis of silicosis. Previous studies found that abnormal expression of various microRNAs (miRNAs) involved in the development of lung fibrosis. However, their roles in silicosis have not been elucidated. To research the biological effects of miR-34a in EMT process in silica-induced lung fibrosis, we established the silicosis model in mouse and miR-34a intervention in a cell model of TGF-β1 stimulated lung epithelial cells (A549). The results showed that miR-34a expression was down-regulated in the fibrotic lung tissue after silica treatment, and it was similarly expressed in A549 cells stim

SUBMITTER: Qi Y 

PROVIDER: S-EPMC7579717 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature