Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice.

ABSTRACT: The generation of myelin-forming oligodendrocytes persists throughout life and is regulated by neural activity. Here we tested whether experience-driven changes in oligodendrogenesis are important for memory consolidation. We found that water maze learning promotes oligodendrogenesis and de novo myelination in the cortex and associated white matter tracts. Preventing these learning-induced increases in oligodendrogenesis without affecting existing oligodendrocytes impaired memory consolidation of water maze, as well as contextual fear, memories. These results suggest that de novo myelination tunes activated circuits, promoting coordinated activity that is important for memory consolidation. Consistent with this, contextual fear learning increased the coupling of hippocampal sharp wave ripp

SUBMITTER: Steadman PE 

PROVIDER: S-EPMC7579726 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature