Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis.

ABSTRACT:

Background

Liver cirrhosis is a significant source of morbidity and mortality worldwide. The disease is usually indolent and asymptomatic early in its course while many cirrhotic patients are diagnosed late when severe complications occur. A major challenge is to diagnose advanced fibrosis as early as possible, using simple and non-invasive diagnostics tools. Thrombocytopenia represents advanced fibrosis and portal hypertension (HTN) and most non-invasive scores that predict liver fibrosis incorporate platelets as a strong risk factor. However, little is known about the association between longitudinal changes in platelet counts (PTC), when still within the normal range, and the risk of cirrhosis.

Aim

To explore whether platelet counts trajectories over time, can predict adv

SUBMITTER: Gotlieb N 

PROVIDER: S-EPMC7579756 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature