Cell type-specific genotoxicity in estrogen-exposed ovarian and fallopian epithelium.

ABSTRACT:

Background

Loss of the genomic stability jeopardize genome stability and promote malignancies. A fraction of ovarian cancer (OvCa) arises from pathological mutations of DNA repair genes that result in highly mutagenic genomes. However, it remains elusive why the ovarian epithelial cells are particularly susceptible to the malfunction of genome surveillance system.

Methods

To explore the genotoxic responses in the unique context of microenvironment for ovarian epithelium that is periodically exposed to high-level steroid hormones, we examined estrogen-induced DNA damage by immunofluorescence in OvCa cell lines, animal and human samples.

Results

We found that OvCa cells are burdened with high levels of endogenous DNA damage that is not correlated with genomic replicatio

SUBMITTER: Song L 

PROVIDER: S-EPMC7579787 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature