Deep vein thrombosis inhibitor may play a therapeutic role in post-stroke patients.

ABSTRACT:

Background

Deep vein thrombosis (DVT) is associated with stroke. Here, we hypothesize that genes associated with DVT may also play roles in the development of stroke.

Methods

we firstly conducted large-scale literature based disease-gene relationship data analysis to explore the genes implicated with DVT and stroke. Further, a mega-analysis was conducted for each of these genes that were linked to DVT but not stroke, using 11 independent stroke RNA expression datasets (176 stroke cases and 102 healthy controls). Then, a multiple linear regression (MLR) model was employed to study possible influential factors on the gene expression levels in stroke. After that, a functional pathway analysis was performed to identify the potential biological linkage between stroke and the targ

SUBMITTER: Xiang X 

PROVIDER: S-EPMC7579790 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature