Genomic amplification of chromosome 20q13.33 is the early biomarker for the development of sporadic colorectal carcinoma.

ABSTRACT:

Background

Colorectal carcinoma (CRC) is the third most common cancer in the world and also the third leading cause of cancer-related mortality in Taiwan. CRC tumorigenesis is a multistep process, starting from mutations causing loss of function of tumor suppressor genes, canonically demonstrated in adenomatous polyposis coli pathogenesis. Although many genes or chromosomal alterations have been shown to be involved in this process, there are still unrecognized molecular events within CRC tumorigenesis. Elucidating these mechanisms may help improve the management and treatment.

Methods

In this study, we aimed to identify copy number alteration of the smallest chromosomal regions that is significantly associated with sporadic CRC tumorigenesis using high-resolution array-base

SUBMITTER: Bui VM 

PROVIDER: S-EPMC7579792 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature