Lack of association between circulating apelin level and frailty-related functional parameters in older adults: a cross-sectional study.

ABSTRACT:

Background

Apelin, an active endogenous peptide, has been recently receiving great attention as a promising target for antiaging intervention, primarily based on results from genetically altered mice. To validate previous experimental data and investigate the possible role of apelin in humans, in this study, we examined serum apelin level in relation to frailty and its associated parameters in a cohort of ambulatory, community-dwelling older adults.

Methods

Blood samples were collected from 80 participants who underwent a comprehensive geriatric assessment, and apelin level was measured using an enzyme immunoassay kit. Phenotypic frailty and deficit-accumulation frailty index (FI) were assessed using widely validated approaches, proposed by Fried and Rockwood groups, respect

SUBMITTER: Jang IY 

PROVIDER: S-EPMC7579806 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature