Interactive effects of asparagine and aspartate homeostasis with sex and age for the risk of type 2 diabetes risk.

ABSTRACT:

Background

Asparagine and aspartate homeostasis are linked with type 2 diabetes (T2D). This study aimed to explore whether asparagine and aspartate metabolism interacted with sex and age to increase the risk of T2D.

Methods

From 27 May 2015 to 3 August 2016, we consecutively retrieved 1032 T2D patients and 1522 subjects without T2D from a tertiary care hospital in Liaoning, China. Restricted cubic spline nested in the logistic regression was used to draw odds ratio curves of plasma asparagine to aspartate ratio for T2D by sex and age. Cut-off point was selected where curves went apart, indicating possible interaction. Addictive interactions of asparagine to aspartate ratio with sex or age and secondary interaction with copresence of unfavorable sex and age were further estim

SUBMITTER: Luo HH 

PROVIDER: S-EPMC7579815 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature