Understanding the molecular association between hyperkalemia and lung squamous cell carcinomas.

ABSTRACT:

Background

Previous studies indicated a strong association between hyperkalemia and lung squamous cell carcinomas (LSCC). However, the underlying mechanism is not fully understood so far.

Methods

Literature-based data mining was conducted to identify genes, molecule, and cell processes linked to both hyperkalemia and LSCC. Pathway analysis was performed to explore the interactive network, common-target network, and common-regulator network for both disorders. Then, a mega-analysis using 11 independent LSCC RNA expression datasets (358 LSCCs and 278 healthy controls) was performed to test the hypothesis that genes influencing hyperkalemia may also play roles in LSCC.

Results

There was a significant overlap between the genes implicated with both diseases (20 genes, p-va

SUBMITTER: Meng X 

PROVIDER: S-EPMC7579872 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature