Using optimal control to understand complex metabolic pathways.

ABSTRACT:

Background

Optimality principles have been used to explain the structure and behavior of living matter at different levels of organization, from basic phenomena at the molecular level, up to complex dynamics in whole populations. Most of these studies have assumed a single-criteria approach. Such optimality principles have been justified from an evolutionary perspective. In the context of the cell, previous studies have shown how dynamics of gene expression in small metabolic models can be explained assuming that cells have developed optimal adaptation strategies. Most of these works have considered rather simplified representations, such as small linear pathways, or reduced networks with a single branching point, and a single objective for the optimality criteria.

Results

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SUBMITTER: Tsiantis N 

PROVIDER: S-EPMC7579911 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature