PyGNA: a unified framework for geneset network analysis.

ABSTRACT:

Background

Gene and protein interaction experiments provide unique opportunities to study the molecular wiring of a cell. Integrating high-throughput functional genomics data with this information can help identifying networks associated with complex diseases and phenotypes.

Results

Here we introduce an integrated statistical framework to test network properties of single and multiple genesets under different interaction models. We implemented this framework as an open-source software, called Python Geneset Network Analysis (PyGNA). Our software is designed for easy integration into existing analysis pipelines and to generate high quality figures and reports. We also developed PyGNA to take advantage of multi-core systems to generate calibrated null distributions on large da

SUBMITTER: Fanfani V 

PROVIDER: S-EPMC7579948 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature