Estimation in meta-analyses of response ratios.

ABSTRACT:

Background

For outcomes that studies report as the means in the treatment and control groups, some medical applications and nearly half of meta-analyses in ecology express the effect as the ratio of means (RoM), also called the response ratio (RR), analyzed in the logarithmic scale as the log-response-ratio, LRR.

Methods

In random-effects meta-analysis of LRR, with normal and lognormal data, we studied the performance of estimators of the between-study variance, τ², (measured by bias and coverage) in assessing heterogeneity of study-level effects, and also the performance of related estimators of the overall effect in the log scale, λ. We obtained additional empirical evidence from two examples.

Results

The results of our extensive simulations showed severa

SUBMITTER: Bakbergenuly I 

PROVIDER: S-EPMC7579974 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature