The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis.

ABSTRACT:

Background

Replication studies showed conflicting effects of ABCG2 and SLC2A9 polymorphisms on gout and serum urate. This meta-analysis therefore aimed to pool their effects across studies.

Methods

Studies were located from MEDLINE and Scopus from inception to 17th June 2018. Observational studies in adults with any polymorphism in ABCG2 or SLC2A9, and outcome including gout, hyperuricemia, and serum urate were included for pooling. Data extractions were performed by two independent reviewers. Genotype effects were pooled stratified by ethnicity using a mixed-effect logistic model and a multivariate meta-analysis for dichotomous and continuous outcomes.

Results

Fifty-two studies were included in the analysis. For ABCG2 polymorphisms, mainly studied in Asians, carrying

SUBMITTER: Lukkunaprasit T 

PROVIDER: S-EPMC7580000 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature