Stage-specific protein-domain mutational profile of invasive ductal breast cancer.

ABSTRACT:

Background

Understanding the mechanisms underlying the malignant progression of cancer cells is crucial for early diagnosis and therapeutic treatment for cancer. Mutational heterogeneity of breast cancer suggests that about a dozen of cancer genes consistently mutate, together with many other genes mutating occasionally, in patients.

Methods

Using the whole-exome sequences and clinical information of 468 patients in the TCGA project data portal, we analyzed mutated protein domains and signaling pathway alterations in order to understand how infrequent mutations contribute aggregately to tumor progression in different stages.

Results

Our findings suggest that while the spectrum of mutated domains was diverse, mutations were aggregated in Pkinase, Pkinase Tyr, Y-Phospha

SUBMITTER: Yu T 

PROVIDER: S-EPMC7580001 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature