Associations of equol-producing status with white matter lesion and amyloid-β deposition in cognitively normal elderly Japanese.

ABSTRACT:

Introduction

Equol, a metabolite of a soy isoflavone transformed by the gut microbiome, is anti-oxidant and anti-amyloidogenic. We assessed the associations of equol with white matter lesion normalized to total brain volume (WML%) and amyloid beta (Aβ) deposition.

Methods

From 2016 to 2018, 91 cognitively normal elderly Japanese aged 75 to 89 underwent brain magnetic resonance imaging and positron emission tomography using ¹¹C-Pittsburgh compound-B. Serum equol was measured using stored samples from 2008 to 2012. Equol producers were defined as individuals with serum levels >0. Producers were further divided into high (> the median) and low (≤ the median) producers.

Results

The median (interquartile range) WML% was 1.10 (0.59 to 1.61); 24.2% were Aβ positiv

SUBMITTER: Sekikawa A 

PROVIDER: S-EPMC7580022 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature