Histone Methylation: Achilles Heel and Powerful Mediator of Periodontal Homeostasis.

ABSTRACT: The packaging of DNA around nucleosomes exerts dynamic control over eukaryotic gene expression either by granting access to the transcriptional machinery in an open chromatin state or by silencing transcription via chromatin compaction. Histone methylation modification affects chromatin through the addition of methyl groups to lysine or arginine residues of histones H3 and H4 by means of histone methyl transferases or histone demethylases. Changes in histone methylation state modulate periodontal gene expression and have profound effects on periodontal development, health, and therapy. At the onset of periodontal development, progenitor cell populations such as dental follicle cells are characterized by an open H3K4me3 chromatin mark on RUNX2, MSX2, and DLX5 gene promoters. During further

SUBMITTER: Francis M 

PROVIDER: S-EPMC7580172 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature