Alterations of Gut Microbiome and Metabolite Profiling in Mice Infected by Schistosoma japonicum.

ABSTRACT: Schistosoma japonicum (S. japonicum) is one of the etiological agents of schistosomiasis, a widespread zoonotic parasitic disease. However, the mechanism of the balanced co-existence between the host immune system and S. japonicum as well as their complex interaction remains unclear. In this study, 16S rRNA gene sequencing, combined with metagenomic sequencing approach as well as ultraperformance liquid chromatography-mass spectrometry metabolic profiling, was applied to demonstrate changes in the gut microbiome community structure during schistosomiasis progression, the functional interactions between the gut bacteria and S. japonicum infection in BALB/c mice, and the dynamic metabolite changes of the host. The results showed that both gut microbiome and

SUBMITTER: Hu Y 

PROVIDER: S-EPMC7580221 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature