β-Glucan as Trained Immunity-Based Adjuvants for Rabies Vaccines in Dogs.

ABSTRACT: The mechanisms of trained immunity have been extensively described in vitro and the beneficial effects are starting to be deciphered in in vivo settings. Prototypical compounds inducing trained immunity, such as β-glucans, act through epigenetic reprogramming and metabolic changes of innate immune cells. The recent advances in this field have opened new areas for the development of Trained immunity-based adjuvants (TIbAs). In this study, we assessed in dogs the potential immune training effects of β-glucans as well as their capacity to enhance the adaptive immune response of an inactivated rabies vaccine (Rabisin^®). Injection of β-glucan from Euglena gracilis was performed 1 month before vaccination with Rabisin^® supplemented or not with the same

SUBMITTER: Paris S 

PROVIDER: S-EPMC7580252 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature