Antibacterial Activity of Bacillus inaquosorum Strain T1 against pirABVp -Bearing Vibrio parahaemolyticus: Genetic and Physiological Characterization.

ABSTRACT: Acute hepatopancreatic necrosis disease (AHPND) is caused by PirAB toxin-producing Vibrio parahaemolyticus and has devastated the global shrimp aquaculture industry. One approach for preventing the growth of AHPND-producing Vibrio spp. is through the application of beneficial bacteria capable of inhibiting these pathogens. In this study, we focused on the inhibitory activity of Bacillus inaquosorum strain T1, which hinders V. parahaemolyticus growth in coculture experiments in a density-dependent manner; inhibition was also observed using cell-free supernatants from T1 stationary-phase cultures. Using mariner-based transposon mutagenesis, 17 mutants having a complete or partial loss of inhibitory activity were identified. Of those displaying a total loss of activity, 13 had insertions with

SUBMITTER: Avery SE 

PROVIDER: S-EPMC7580553 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature