Whole-genome sequencing of rough Brucella melitensis in China provides insights into its genetic features.

ABSTRACT: Brucella spp. can cause the zoonosis brucellosis, which affects public health and safety and even economic development. B. melitensis has a smooth phenotype, while 28 B. melitensis isolates had a rough phenotype in 2018. In this study, rough phenotype detection and whole genome sequencing methods were used to analyze the genetic features of rough B. melitensis. A drug susceptibility test was also performed. The results showed that the rough B. melitensis strains originated from strains isolated in China rather than from foreign strains. Furthermore, an MS tree showed that 9 complexes to be epidemic in China. For the rough B. melitensis strains, expression of the metabolic function genes varied in the earlier stages of evolution compared to the cell

SUBMITTER: Yang X 

PROVIDER: S-EPMC7580580 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature