Pharmacokinetics and biodistribution of a collagen-targeted peptide amphiphile for cardiovascular applications.

ABSTRACT: Atherosclerosis remains a leading cause of death and disability around the world and a major driver of health care spending. Nanomaterials have gained widespread attention due to their promising potential for clinical translation and use. We have developed a collagen-targeted peptide amphiphile (PA)-based nanofiber for the prevention of neointimal hyperplasia after arterial injury. Our goal was to characterize the pharmacokinetics and biodistribution of the collagen-targeted PA to further its advancement into clinical trials. Collagen-targeted PA was injected into the internal jugular vein of Sprague Dawley rats. PA concentrations in plasma collected at various times after injection (0 to 72 hours) were measured by liquid chromatography-tandem mass spectrometry. Pharmacokinetics of the col

SUBMITTER: Kassam HA 

PROVIDER: S-EPMC7580710 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature