Synthesis and in vivo evaluation of a radiofluorinated ketone body derivative.

ABSTRACT: The ketone bodies d-beta-hydroxybutyric acid and acetoacetic acid represent the principal oxidative energy sources of most tissues when dietary glucose is scarce. An ¹⁸F-labeled ketone body could be a useful tool for studying ketone body metabolism using positron emission tomography (PET). Here, we report the first radiofluorinated ketone body derivative (3S)-4-[¹⁸F]fluoro-3-hydroxybutyric acid ([¹⁸F]FBHB) as well as its enantiomer and l-beta-hydroxybutyric acid derivative, (3R)-4-[¹⁸F]fluoro-3-hydroxybutyric acid ((R)-[¹⁸F]F3HB). PET imaging in mice showed biodistribution profiles of the radiotracers that were consistent with the biodistribution of the respective endogenous compounds. Moreover, both enantiomers vi

SUBMITTER: Mattingly SJ 

PROVIDER: S-EPMC7580772 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature