Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis.

ABSTRACT: A major obstacle to treating Alzheimer's disease (AD) is our lack of understanding of the molecular mechanisms underlying selective neuronal vulnerability, a key characteristic of the disease. Here, we present a framework integrating high-quality neuron-type-specific molecular profiles across the lifetime of the healthy mouse, which we generated using bacTRAP, with postmortem human functional genomics and quantitative genetics data. We demonstrate human-mouse conservation of cellular taxonomy at the molecular level for neurons vulnerable and resistant in AD, identify specific genes and pathways associated with AD neuropathology, and pinpoint a specific functional gene module underlying selective vulnerability, enriched in processes associated with axonal remodeling, and affected by amyloid

SUBMITTER: Roussarie JP 

PROVIDER: S-EPMC7580783 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature