Positive selection in admixed populations from Ethiopia.

ABSTRACT:

Background

In the process of adaptation of humans to their environment, positive or adaptive selection has played a main role. Positive selection has, however, been under-studied in African populations, despite their diversity and importance for understanding human history.

Results

Here, we have used 119 available whole-genome sequences from five Ethiopian populations (Amhara, Oromo, Somali, Wolayta and Gumuz) to investigate the modes and targets of positive selection in this part of the world. The site frequency spectrum-based test SFselect was applied to idfentify a wide range of events of selection (old and recent), and the haplotype-based statistic integrated haplotype score to detect more recent events, in each case with evaluation of the significance of candidate signa

SUBMITTER: Walsh S 

PROVIDER: S-EPMC7580818 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature