Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver.

ABSTRACT:

Rationale

Dysbiosis of gut microbiota plays an important role in cardiovascular diseases but the molecular mechanisms are complex. An association between gut microbiome and the variance in HDL-C (high-density lipoprotein-cholesterol) level was suggested in a human study. Besides, dietary fat was shown to increase both HDL-C and LDL-C (low-density lipoprotein-cholesterol) levels. We speculate that certain types of gut bacteria responding to dietary fat may help to regulate HDL-C level and potentially affect atherosclerotic development.

Objective

We aimed to investigate whether and how high-fat diet (HFD)-associated gut microbiota regulated HDL-C level.

Methods and results

We found that HFD increased gut flagellated bacteria population in mice. The increase in HDL-C lev

SUBMITTER: Yiu JHC 

PROVIDER: S-EPMC7580858 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature