The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.

ABSTRACT: To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months aft

SUBMITTER: Garrett-Bakelman FE 

PROVIDER: S-EPMC7580864 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature