Herpes simplex virus type 1 infection leads to neurodevelopmental disorder-associated neuropathological changes.

ABSTRACT: Neonatal herpes simplex virus type 1 (HSV-1) infections contribute to various neurodevelopmental disabilities and the subsequent long-term neurological sequelae into the adulthood. However, further understanding of fetal brain development and the potential neuropathological effects of the HSV-1 infection are hampered by the limitations of existing neurodevelopmental models due to the dramatic differences between humans and other mammalians. Here we generated in vitro neurodevelopmental disorder models including human induced pluripotent stem cell (hiPSC)-based monolayer neuronal differentiation, three-dimensional (3D) neuroepithelial bud, and 3D cerebral organoid to study fetal brain development and the potential neuropathological effects induced by the HSV-1 infections. Our results reveal

SUBMITTER: Qiao H 

PROVIDER: S-EPMC7580908 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature