Meta-analysis of the association between adiponectin SNP 45, SNP 276, and type 2 diabetes mellitus.

ABSTRACT:

Objective

The present study aimed to determine whether the polymorphisms at rs2241766 and rs1501299 on the ADIPOQ gene were related to the susceptibility of type 2 diabetes mellitus (T2DM).

Methods

Eight databases, PubMed, GWAS, Embase, Lochrane, Ebsco, CNKI (Chinese National Knowledge Infrastructure), VIP (Viper Database) and ChinaInfo were searched, and a meta-analysis of susceptibility was conducted between SNP45, SNP276 polymorphisms and T2DM. Furthermore, HWE test was conducted to assess the genetic balance of the study, evaluate the quality of Newcastle-Ottawa quality assessment scale (NOS), and establishing allelic, dominant, recessive, heterozygous, and homozygous gene models.

Results

This meta-analysis included 53 articles, encompassing 9285 cases with rs2241

SUBMITTER: Dong Y 

PROVIDER: S-EPMC7580922 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature