Magnetic Resonance Imaging for Evaluation of Interstitial Fibrosis in Kidney Allografts.

ABSTRACT: Interstitial fibrosis (IF) is the common pathway of chronic kidney injury in various conditions. Magnetic resonance imaging (MRI) may be a promising tool for the noninvasive assessment of IF in renal allografts.

Methods

This prospective trial was primarily designed to investigate whether the results of T1-weighted MRI associate with the degree of IF. Thirty-two kidney transplant recipients were subjected to 1.5-Tesla MRI scans shortly before or after routine allograft biopsies. MRI parameters [T1 and T2 relaxation times; apparent diffusion coefficient (ADC)] were assessed for cortical and medullary sections.

Results

Advanced IF (Banff ci score >1) was associated with higher cortical T1 (but not T2) values [1451 (median; interquartile range: 1331-1506) versus 1306 (1197-1321)

SUBMITTER: Beck-Tolly A 

PROVIDER: S-EPMC7581173 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature