Local Recurrence Following Total Marrow Radiation: Implications for Clinical Target Delineation.

ABSTRACT: Total marrow radiation is an emerging treatment modality used in patients undergoing stem cell transplantation. We present a rare case of a patient undergoing total marrow irradiation with concurrent ablative stem cell transplantation with local failures in two out-of-field areas that were not included in the clinical target volume A 31-year-old female patient initially presented with abdominal pain secondary to chronic myelogenous leukemia. She underwent dasatinib treatment for years, but subsequently developed recurrence and underwent consolidation systemic chemotherapy followed by allogeneic stem cell transplantation with adjuvant total marrow irradiation. Several months later, she noticed increased left jaw swelling and dysphagia with associated right ankle swelling. Biopsy of the righ

SUBMITTER: Hara JH 

PROVIDER: S-EPMC7581219 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature