Catalytic Reductive Alkylation of Amines in Batch and Microflow Conditions Using a Silicon-Wafer-Based Palladium Nanocatalyst.

ABSTRACT: We describe the development of the catalytic reductive alkylation of amines with aldehydes under the atmospheric pressure of H₂ using a brush-like silicon-nanostructure-supported palladium nanoparticle composite (SiNS-Pd) as a silicon-wafer-based reusable heterogeneous catalyst. The present reaction of primary and secondary amines with various aliphatic and aromatic aldehydes in the presence of the catalyst (0.02-0.05 mol % Pd) gave the corresponding secondary and tertiary amines including Lomerizine and Aticaprant in a 68% quantitative yield without overalkylation. We also designed and fabricated a flow device equipped with SiNS-Pd for microflow reactions, which was applied to the gas-liquid-solid triphasic reaction system (i.e., H₂ gas, a substrate solution, and a s

SUBMITTER: Sato T 

PROVIDER: S-EPMC7581266 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature