Potential SARS-CoV-2 interactions with proteins involved in trophoblast functions - An in-silico study.

ABSTRACT:

Background

Though a large number of pregnant females have been affected by COVID-19, there is a dearth of information on the effects of SARS-CoV-2 infection on trophoblast function. We explored in silico, the potential interactions between SARS-CoV-2 proteins and proteins involved in the key functions of placenta.

Methods

Human proteins interacting with SARS-CoV-2 proteins were identified by Gordon et al. (2020). Genes that are upregulated in trophoblast sub-types and stages were obtained by gene-expression data from NCBI-GEO and by text-mining. Genes altered in pathological states like pre-eclampsia and gestational diabetes mellitus were also identified. Genes crucial in placental functions thus identified were compared to the SARS-CoV-2 interactome for overlaps. Proteins r

SUBMITTER: Seethy AA 

PROVIDER: S-EPMC7581362 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature