Compartmental immunophenotyping in COVID-19 ARDS: A case series.

ABSTRACT:

Background

Severe immunopathology may drive the deleterious manifestations that are observed in the advanced stages of coronavirus disease 2019 (COVID-19) but are poorly understood.

Objective

Our aim was to phenotype leukocyte subpopulations and the cytokine milieu in the lungs and blood of critically ill patients with COVID-19 acute respiratory distress syndrome (ARDS).

Methods

We consecutively included patients less than 72 hours after intubation following informed consent from their next of kin. Bronchoalveolar lavage fluid was evaluated by microscopy; bronchoalveolar lavage fluid and blood were assessed by 10-color flow cytometry and a multiplex cytokine panel.

Results

Four mechanically ventilated patients (aged 40-75 years) with moderate-to-severe COVID-19

SUBMITTER: Ronit A 

PROVIDER: S-EPMC7581505 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature