RCSB Protein Data Bank tools for 3D structure-guided cancer research: human papillomavirus (HPV) case study.

ABSTRACT: Atomic-level three-dimensional (3D) structure data for biological macromolecules often prove critical to dissecting and understanding the precise mechanisms of action of cancer-related proteins and their diverse roles in oncogenic transformation, proliferation, and metastasis. They are also used extensively to identify potentially druggable targets and facilitate discovery and development of both small-molecule and biologic drugs that are today benefiting individuals diagnosed with cancer around the world. 3D structures of biomolecules (including proteins, DNA, RNA, and their complexes with one another, drugs, and other small molecules) are freely distributed by the open-access Protein Data Bank (PDB). This global data repository is used by millions of scientists and educators working in t

SUBMITTER: Goodsell DS 

PROVIDER: S-EPMC7581513 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature